Prof. Dr. rer. nat. Christoph Hoeschen
Prof. Dr. rer. nat. Christoph Hoeschen
Lehrstuhl für Medizintechnische Systeme
Aktuelle Projekte
IMMPRINT: Integrated molecular Imaging for Personalized Biomarker-based Breast Cancer Characterization and Treatment
Laufzeit: 01.04.2024 bis 01.03.2027
Molecular medical imaging plays a crucial role in modern medical diagnosis, enabling early and personalized therapy for various diseases, especially cancer. However, existing in vivo medical imaging methods have limitations for molecular imaging in humans, such as low sensitivity to molecular processes, limited spatial and temporal resolution, or high exposure to ionizing radiation. To address these challenges, IMMPRINT aims to develop a proof-of-principle demonstrator for in vivo 3D imaging, utilizing X-ray dark-field imaging (DFI) and X-ray fluorescence computed tomography (XFCT) as a novel hybrid tool for personalised tumor profiling, with a specific focus on breast cancer (BC) disease.
DFI will aid the identification of suspicious tumor lesion sites at micrometer scales, followed by a detailed high spatial resolution molecular assessment at the local tumor level using XFCT. As a result of this approach, exposure to body-wide high ionizing radiation doses, as seen in nuclear medical imaging methods, can be confined to regions of interest, thus promoting patient safety. The DF-XFCT will rely on various pillars of innovative technology development, from novel detectors to integrated in vivo, in vitro bio-diagnostics. X-ray fluorescence is emitted when nanoparticles are excited by X-rays. Within IMMPRINT, distinct signatures of intra- and inter-tumor heterogeneity in BC will be identified, which are suitable for detection by specifically designed and targeted nanoparticles. The IMMPRINT system for hybrid DF-XFCT imaging will include standard clinical X-ray sources and will benefit from innovative detectors, enabling concurrent detection of DFI and XFCT, aimed at high spatial and energy resolution.
The unequally distributed data, which includes timing and energy information, requires the development of new methods to extract 3D imaging information from this data, providing insights into the functional, molecular, and anatomical properties of BC disease. The IMMPRINT imaging system will allow new approaches for better medical diagnosis and also new biomedical research. It will demonstrate the technical feasibility on the lab scale and potentially form the basis for the commercial development of a system. The consortium unites expertise from all fields mentioned above and is using nationally and internationally funded large-scale infrastructures.
IMAGEOMICS: Optimizing Benefit/Risk Ratio in Breast Cancer Diagnosis and Radiotherapy: Identifying Molecular, Cellular and Imaging Signatures of Breast Cancer Heterogeneity to Improve Personalized Therapeutic Strategies for Synergistic Treatment Combinations
Laufzeit: 01.02.2024 bis 01.01.2027
The main aims of IMAGEOMICS are to improve benefit/risk ratio of breast cancer (BC) patients by identifying patients with a predicted favourable response to combined radiotherapy (RT) and immunotherapy and to develop new imaging modality with increased diagnostic potential and reduced ionizing radiation exposure. These aims will be realized through the following specific objectives: a) investigate how RT influences immunogenic heterogeneity of BC cells of different molecular subtypes using in vitro and in vivo approaches; b) test the applicability of nanoparticles for X ray fluorescence computed tomography (XFCT) to be used for the detection of BC heterogeneity; c) to identify local and systemic signatures that predict patient benefit from combined RT and immunotherapy and test their clinical applicability; d) to integrate data retrieved from experimental models and human studies with epidemiological data to build up a protocol for optimal patient stratification.
breath gas analysis of tuberculosis or lung cancer patients
Laufzeit: 01.12.2016 bis 31.12.2024
Lung tuberculosis is an infection of the lungs which had been assumed to be wiped out in modern developed countries. However, there is again a rising number of cases. In addition, due tot he large number of refugees there are additional needs for characterising possible infections early. This is especially true as tuberculosis is still one oft he most often infectual diseases worldwide. X-ray imaging is at least for young patients not an easy to justify procedure. The gold standard for the diagnosis of tuberculosis is the cultural biology prove of Mycobacterium tuberculosis. This is quite a long and complicated procedure. It would be desirable to have a fast and easy diagnostic tool instead, because that could foster the in principle very effective therapy approaches, if applied in early stages. Since we know from earlier studies that breath gas analysis allows the detection of changes in the metabolism and especially those caused by infections we investigate the feasiblity to diagnose tuberculosis with breath gas analysis.
Interventional molecular imaging
Laufzeit: 01.12.2016 bis 31.12.2024
Molecular imaging, such as Positron Emission Tomography has an important
impact in diagnostic, while it started only recently to be integrated into interventional procedures. Interventional molecular imaging
can provide guidance to localize a target; provide in-room, post-therapy assessment; monitoring of targeted therapeutics delivery.
Interventional molecular imaging is generally based on commercial whole-body PET/CT scanners, which limit the possibility of an entire surgical guidance
procedure, while on-site integration of dedicated devices would definitely benefit the entire guidance.
This project focuses on the study of a dedicated detector, and the potential impact of its integration in brain interventional procedures.
Abgeschlossene Projekte
i-Violin:Implementing verifiable oncological imaging by quality assurance and optimisation
Laufzeit: 01.09.2022 bis 31.08.2024
Ein internationales Forschungsteam wird europaweit gültige Qualitäts- und Sicherheitsstandards für die Anwendung ionisierender Strahlung bei der Diagnose und Behandlung von Krebserkrankungen entwickeln. Dazu wird eine europäische Datenbank mit patientenspezifischen Diagnose- und Therapiedaten sowie Behandlungsempfehlungen aufgebaut. Diese Datenbank soll über Ländergrenzen hinweg vergleichbare Standards bei der Anwendung ionisierender Strahlen sicherstellen und den Medizinern helfen, die Strahlenbelastung von Patientinnen und Patienten auf ein sinnvolles Maß zu reduzieren, individuell zu optimieren und somit die Sicherheit und Qualität in der Versorgung von Tumorerkrankten europaweit verbessern.
Im Zentrum des Forschungsprojektes steht die Frage, inwiefern die Qualität der diagnostischen Bildgebung, zum Beispiel von Computertomografien, mit der verabreichten Dosis und dem Strahlentherapieerfolg in einem direkten Zusammenhang steht und so optimiert werden kann, dass die Behandlung des Patienten mit möglichst geringen Nebenwirkungen und möglichst wenigen langfristigen negativen Effekten für den einzelnen Patienten durchgeführt werden kann.
Um dieses Ziel zu erreichen, wird in einem ersten Schritt eine in Vorprojekten entwickelte Software zur Bewertung der Bildqualität von Computertomografien in 5 beteiligten europäischen Krankenhäusern eingeführt. Später sollen die u.a. in Magdeburg entwickelten Verfahren in möglichst vielen europäischen Kliniken zum Einsatz kommen.
Das Projekt i-Violin wird gefördert durch das EU4Health Gesundheitsprogramm und unterstützt das Ziel des europäischen Plans, zur Krebsbekämpfung (Europe’s Beating Cancer Plan) hohe Standards in der Krebsbehandlung sicherzustellen. Außerdem sind es der SAMIRA-Aktionplan sowie die strategische Forschungsagenda von ESR EuroSafe Imaging und EURAMED Programme, die sich in i-Violin wiederfinden. Die Partnereinrichtungen sind das European Institute for Biomedical Imaging Research, die Otto-von-Guericke-Universität Magdeburg, die Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, das Polytechnic Institute of Coimbra in Portugal, die University of Crete, Greece, das Clinical Hospital Dubrava in Kroatien, die University Medical Centre Ljubljana, Slowenien, KU Leuven in Belgien, das University College Dublin, und die National University of Ireland Dublin in Irland sowie die Finnish Radiation and Nuclear Safety Authority in Finnland.
SINFONIA -Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour
Laufzeit: 01.09.2020 bis 31.08.2024
The overall objective of the 4-year SINFONIA project is to develop novel research methodologies and tools that will provide a comprehensive appraisal of the risk for detrimental effects to patients, workers, the public and the environment from radiation exposure during management of patients suspected or diagnosed with lymphoma and brain tumours.
SINFONIA will develop novel tools and methodologies that will be demonstrated on two suitable clinical examples i.e. lymphoma and brain tumours. However, SINFONIA research outcomes are not confined to the two specific types of diseases. Some of the procedures performed on lymphoma and brain tumour patients are also carried out on patients with other diseases and SINFONIA radiation dose and risk appraisal methods developed for these two groups of patients will be applicable to other diseases
GEPRIS - Signaturen aus der Atemluft bei der Depression: Stressbezogene Veränderungen im Ausatemsignal während der Frühphase des Krankheitsmanagement
Laufzeit: 01.03.2021 bis 29.02.2024
Etwa ein Drittel der Patienten mit einer depressiven Störung (MDD) spricht nicht auf mindestens zwei verschiedene Therapien mit Antidepressiva an. Diese Betroffenen bräuchten so früh wie möglich andere Behandlungsoptionen. Leider gibt es derzeit keine nicht-invasiven, leicht und häufig anwendbaren Biomarker, die die Diagnose einer unipolaren depressiven Störung (MDD) erleichtern oder die Entscheidungsfindung zur Therapiewahl unterstützen könnten. Da die Lunge als Gasaustauscher zwischen der inneren und äußeren Umgebung fungiert, könnten die Auswirkungen der MDD leicht durch die Analyse des ausgeatmeten Atems beurteilt werden. Solche Verfahren werden bereits beim Alkoholtest und beim Diabetes mellitus erfolgreich eingesetzt. In einer Pilotstudie an 25 Patienten mit MDD und 25 gesunden Probanden konnten wir Marker finden, die sich signifikant zwischen den Gruppen unterscheiden und die eine gute Klassifikation mit einer Genauigkeit von über 80 % in Test- und Validierungssamples ergaben. Ziel der Studie ist es Signaturen aus der Ausatemluft zu identifizieren, die eine depressive Episode bei MDD und vom gesunden Zustand unterscheiden. Außerdem soll untersucht werden, durch welche Faktoren (Behandlung, Ernährung, Umwelt) diese Signaturen beeinflusst werden, ob die identifizierten Signaturen Hinweise auf den Krankheitsverlauf geben können und ob sie Parallelen zur Dysregulation der Kortisolantwort während des Aufwachens, die bei der Depression gezeigt wurde, aufweisen. Es werden in einem Testsample 80 Patienten mit MDD nach DSM-V (davon 40 aktuell frei von antidepressiver medikamentöser Behandlung und 40 mit laufender antidepressiver Behandlung) und 80 gesunde Probanden eingeschlossen. Des Weiteren werden in einem Bestätigungssample 40 Patienten mit MDD (davon 20 derzeit frei von antidepressiver medikamentöser Behandlung und 20 mit laufender antidepressiver Behandlung) und 40 gesunde Probanden rekrutiert. Die klinischen Untersuchungen und die Atemluftmessungen werden nach 14 und 28 Tagen wiederholt. Die Analyse der Atemluft erfolgt mittels Protonentransferreaktionsmassenspektrometrie (PTR-TOF-MS). Zusätzlich wird eine Bestimmung der dahinterliegenden Substanzen mit GC-GC-TOF-MS durchgeführt. Die Umgebungsbedingungen und die Sammelmethode mittels "Tedlar"-Beuteln werden kontrolliert. Dadurch wollen wir einen Marker entwickeln mit dem die Diagnose Depression unterstützt werden könnte, wobei dies danach in einer klinischen Biomarkerstudie gezeigt werden muss.
KI-INSPIRE: Verbund - KI: Künstliche Intelligenz für den innovativen nachhaltigen Strahlenschutz von Patienten in interventionellen radiologischen Einsatzgebieten
Laufzeit: 01.12.2020 bis 31.12.2023
Auf dem Gebiet der Medizinphysik und Medizintechnik ist die Nutzung von KI-basierten Verfahren besonders im Bereich des Strahlenschutzes und hier insbesondere in der medizinischen Bildgebung, die für nahezu 100% der zivilisatorischen Strahlenexposition von 1,9 mSv pro Jahr verantwortlich ist [Unterrichtung durch die Bundesregierung: Umweltradioaktivität und Strahlenbelastung im Jahr 2013], äußerst vielversprechend. Dort ließe sich dank der neuen disruptiven Technologien von KI ein enormes Dosiseinsparpotential realisieren.
Das Ziel des Verbundvorhabens ist daher die Entwicklung, Implementierung und Erprobung von KI-Verfahren zur signifikanten Reduktion der Strahlendosis in der medizinischen Bildgebung mit ionisierender Strahlung. Dies soll durch Verbesserung der Bildqualität und des Strahlenschutzes für medizinische Bildgebungsverfahren basierend auf ionisierender Strahlung geschehen.
Um eine ganzheitliche/holistische und systematische Betrachtungsweise zu ermöglichen, adressiert das Projektvorhaben, die interventionelle Bildgebung bei der sowohl diagnostische als auch therapeutische Ziele mit Hilfe von Computertomografie, Angiographie und Nuklearmedizin realisiert werden.
Ein besonderer Fokus liegt dabei auf der Entwicklung und Etablierung intelligenter Algorithmen für (I) die Dosisreduktion, (II) die Verbesserung der Bildqualität und (III) Reduktion der Bewegungsartefakte sowie die (IV) interventionelle Charakterisierung von Gewebe bei medizinischen Strahlenanwendungen - Anwendungen, die alle dem Strahlenschutz zuzuordnen sind. Dabei steht die Erhöhung der Sicherheit für Patienten und medizinisches Personal im Vordergrund, so dass ein wertvoller Beitrag zur positiven Wahrnehmung von KI in der breiten Bevölkerung geleistet werden kann.
EURAMED rocc-n-roll: Erarbeitung einer europäischen Forschungsagenda für die medizinische Anwendung ionisierender Strahlung
Laufzeit: 01.09.2020 bis 31.08.2023
Radiation protection in medical applications is well established throughout Europe, however still facing challenges like large differences in procedures between countries, but even within a country or even within a hospital. In addition, new promising approaches like new technologies as e.g. artificial intelligence or personalized medicine approaches need to be investigated regarding their potential for medical radiation protection. The European Alliance for Medical Radiation Protection Research (EURAMED) platform has been found to promote such research in the EC research programme . Together with five other platforms research in the field of radiation protection is promoted basically in the EURATOM framework. Acknowledging the importance of medical applications as the largest man-made source of exposure and the great possibilities of applying ionizing radiation in medicine the EURATOM programme has launched a call for a coordination and support action to develop a strategic research agenda (SRA) on medical applications of ionizing radiation in general allowing to improve links to other programs like HEALTH or DIGITALIZATION.
A consortium called EURAMED rocc-n-roll has been put together to fulfil the task of developing such an SRA partially based on the existing EURAMED SRA on medical radiation protection. In addition it will also develop a roadmap describing how this research agenda can be implemented. An interlink document showing the potential distributions of the different European research programmes to such defined approaches will also be developed. All these documents need to be derived based on a broad consensus of all stakeholders especially also including the patients’ perspective. Therefore, EURAMED rocc-n-roll is based on a series of workshops and writing panels. The workshops will allow contributions by interested stakeholders in person or through members of the consortium.
OvGU is serving as the scientific coordinator of the project.
breath gas analysis in patients suffering from depression
Laufzeit: 01.01.2019 bis 31.12.2022
According to Smith (Smith, 2011) brain disorders cost Europe almost €800 billion (US$1 trillion) a year - more than cancer, cardiovascular disease and diabetes together.
Major depressive disorders (MDD) can effectively be treated with psychotherapy and/or antidepressants. However, still one third of patients do not respond and would need different treatment options as early as possible (Kennedy and Giacobbe, 2007).
A possible new method for early detection could be breath gas analysis that already was implemented for alcohol tests and recently was found to be clinical applicability e.g. for diabetes detection. Because the lungs act as a gas exchanger between the internal system and external environment, the internal system in disorders like MDD may be assessed through the analysis of exhaled breath especially with respect to stress induced reactions.
X-ray fluorescence and corresponding anatomical imaging
Laufzeit: 01.09.2014 bis 31.12.2022
Molecular imaging today is either limited by systems that provide high resolution spatially and temporarilly but very poor sensitivity to contrast media or molecular markers (CT, MRI) or by such systems that provide high sensitivity but very poor spatial and especially temporal resolution (SPECT, PET). X-ray fluorescence would be an option to overcome such limitations, because in principle it could offer fast scanning, high spatial resolution and a good sensitivity. To gain such efficient approaches one needs scanning geometries with fast steerable X-ray sources which should be adjustable in their beam energy. Such imaging method would on the fly generate an anaomical image as well. We simulate such systems and try to set up demonstration experiments with our cooperation partners.
Advanced X-ray based imaging technologies
Laufzeit: 01.09.2019 bis 31.08.2022
We build systems for dark field and absorption based X-ray imaging systems using for example scanning beam technologies, develop and characterise corresponding detector systems and imaging geometries. The total systems for both different types of imaging systems will be simulated and transferred into prototypes.
Biokinetic von Radiopharmaceutika
Laufzeit: 01.06.2019 bis 30.06.2022
Zur Optimierung des Strahlenschutzes für den Patienten und für eine optimale Bildaufnahme ist es wesentlich die Verteilung der Radiopharmaka im Körper über die Zeit zu kennen. Da dies nicht trivial für jeden Patienten zu messen ist, werden in Kooperation mit Kliniken nuklearmedizinische Daten im Zeitverlauf aufgenommen. Damit werden dynamische Kompartmentmodelle erstellt und die Parameter bestimmt. Die Unsicherheit in der Bestimmung der Parameter und die Sensitivität des Modells für die einzelnen Parameter werden untersucht, um festzustellen, welche Einflußparameter besonders bedeutsam sind. Im Anschluß können reale Patientendaten mit den Modellvorhersagen verglichen werden, um optimierte Zeitschemata für die Bildgebung und optimierte Therapieparameter zu finden bzw. die Dosimetrie für den Patienten zu verbessern.
Breast-CT basierend auf CT dOr
Laufzeit: 01.06.2016 bis 31.12.2021
A newly designed especially developed breast CT system based on the newly developed CT d Or geometry and in this case based on an electron gun with a dedicated delineation system and a special target ring had been set-up. This would allow very fast scanning and a larger covering of the breast volume (closer tot he breast wall) than current breast CT systems, from which very few exist. However, the new geometry requires a very new approach for a detector system because it has tob e separated in columns and the electronics need tob e conserved and should not cover the source positions. We simulate the possible detector design, develop a prototype electronic system and a prototype detector
Darkfield Imaging for breast tissue
Laufzeit: 01.09.2016 bis 30.06.2021
Darkfield imaging relies on differences in the scatter component of the x-ray distribution due to differences instructural conditions oft he tissue. In many approaches this component is a side-product of phase contrast imaging. Since phase contrast imaging is strongly dependent on movements oft he patient and it will be dose intensive for applications in the human tissue characterisation for in vivo imaging, we are concentrating on darkfield X-ray imaging directly. A special system for dose-optimised imaging will be developed. We focus on breast imaging within the current project.
Pharmakokinetik mit molekularer Bildgebung
Laufzeit: 01.05.2019 bis 30.06.2021
Neue molekulare Bildgebungstechniken basierend auf monoenergetischen Röntgenquellen und basierend darauf zum Beispiel auf Röntgenfluoreszenzbildgebung erlauben das Nachverfolgen von Nanopartikeln im Körpern. Koppelt man derartige Nanopartikel an Pharmaka kann man deren Aufenthalt zu verschiedenen Zeitpunkten im Körper nachverfolgen und so die optimale Wirksamkeit der Pharmaka sicher stellen. Die Bildgebung ist noch nicht komplett verfügbar, so dass in diesem Projekt die spezielle Rekonstruktion erarbeitet werden soll, um 3D Darstellungen zu ermöglichen. Zudem müssen die Daten in kinetische Modelle eingepasst werden, um so Vorhersagen über die wahrscheinlichsten Verläufe der Anreicherungen im Körper treffen zu können.
image quality analysis on patient images - EU Projekt MEDIRAD
Laufzeit: 01.06.2017 bis 31.05.2021
Medical imaging quality description is today either based on investigating with objective physical mathematical methods images of certain test objects or on subjective reader evaluations. The objective methods can be either based on methods applicable in the Fourier domain or those in the spatial domain. While analytics in the Fourier domain are often quite easy they are often difficult to interpret in terms of provided diagnostic performance. Image quality analysis in the spatial domain is on the other hand typically limited to very specific tasks and complicated to perform. Human reader studies very often result in very different results and are very time consuming. We want to develop a way to characterise patient images based on physical methods to describe image quality so that fast objective measurements correspond to human reader studies. That would allow qulaity assurance on real patient images in the future.
Robot driven CT with WATCH geometry KaribiCT
Laufzeit: 15.05.2016 bis 30.11.2020
The newly developed geometry for CT applications called WATCH allows a CT scan with variable resolution, in a lying as well as a sitting and standing patient position. It is an open system with easy access fort he radiologist and can be driven by a robot system. However, although the system and the used reconstruction should be very tolerant against movement errors, that would not be the case for geometrical misalignments. Therefore we focus on setting up the robot driven system with a 3D imaging detector and a calibration system. This calibration system can be used for standard CT as well.
Sub-100 ps TOF CRT impact in interventional molecular brain imaging
Laufzeit: 01.08.2015 bis 31.07.2020
Time Of Flight (TOF) capability in PET imaging enhances Signal to Noise Ratio in inverse proportion to the temporal resolution. The Coincidence Resolving Time (CRT) in commercial PET scanners is about 500 ps (FWHM) but current technology limit approaches 10 ps CRT (FWHM) corresponding to 1.5 mm spatial resolution.
TOF increases lesion detection capability, the robustness of iterative reconstruction, and reduces bias in quantification through improved
attenuation, scatter, and random corrections. This investigation studies through simulations the possible enhancements in brain imaging of sub-100 ps CRT technology, in both static and dynamic brain studies.
We will develop prototyp PET detectors.
CT-characterisation of bowtiefilters and parameters for dosimetric calculations
Laufzeit: 01.11.2014 bis 31.12.2019
CT imaging is the largest man-made source of ionising radiation to the public in developed countries as in Germany. Here more than 60% oft he effective dose delivered to patients is due to CT examinations. However, since only small parts oft he body are exposed to ionising radiation, there are quite large dosest o single organs. To evaluate the dose distributions and ist potential effects further it is necessary to determine dose distributions to various organs in detail. Since it is impossible to measure such doses inside the body simulations have tob e performed. There accuracy depends strongly on an exact characterisation oft he CT parameters including calibrating dose measurements and determination or characterisation o feg the bowtie filter of CT systems. There are various measurements developed and performed to characterise bowtie filters and dose values as a basis fort he following simulation of patient dose distributions.
SAFIR - Small Animal Fast Insert for mRi
Laufzeit: 01.10.2016 bis 30.09.2019
SAFIR (Small Animal Fast Insert for mRi) is an innovative, high rate PET detector insert for MRI to be used for quantitative dynamic small animal imaging inside the bore of a commercial 7T MRI preclinical scanner (Bruker 70/30, http://tinyurl.com/BrukerBiospec) at the University Zurich, Institute of Pharmacology and Toxicology. The project targets an unprecedented temporal resolution (about 5 seconds) and truly simultaneous PET/MR acquisition
The use of diamond detectors for dosimetry and microdosimetry assessment in different therapeutic scenarios
Laufzeit: 01.07.2016 bis 30.06.2018
In cancer treatment both ion-beam therapy and alpha radionuclide therapy base their effectiveness on the high ionization density provided by hadrons. However the stochastic nature of the hadron interaction in tissue, and the complexity of the interaction patterns
require a better description of the radiobiological effect of hadrons in tissue that cannot be
adequately reflected, as in conventional radiation therapy, by a single dosimetric quantity,
e.g. mean absorbed dose to target volume. MedAustron, the Austrian centre for ion-beam therapy, in collaboration with the University of Rome, Tor Vergata is developing semi-conductor diamond detectors for dosimetry and microdosimetry in ion-beam therapy. The potential of such (micro)dosimeters with respect to alpha radionuclide target therapy, 90Y radio-embolization, and other treatment modalities is under investigation in the present project.
2024
Artikel in Zeitschrift
3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT
Al-Jaberi, Fadil; Moeskes, Matthias; Skalej, Martin; Fachet, Melanie; Hoeschen, Christoph
In: EJNMMI reports - [Cham] : Springer International Publishing, Bd. 8 (2024), Artikel 17, insges. 21 S.
Begutachteter Zeitschriftenartikel
High-spatial-resolution benchtop X-ray fluorescence imaging through bragg-diffraction-based focusing with bent mosaic graphite crystals - a simulation study
Kumar, Kunal; Fachet, Melanie; Hoeschen, Christoph
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 25 (2024), Heft 9, Artikel 4733, insges. 26 S.
Enabling low-dose in vivo benchtop X-ray fluorescence computed tomography through deep-learning-based denoising
Mahmoodian, Naghmeh; Rezapourian, Mohammad; Inamdar, Asim Abdulsamad; Kumar, Kunal; Fachet, Melanie; Hoeschen, Christoph
In: Journal of imaging - Basel : MDPI, Bd. 10 (2024), Heft 6, Artikel 127, insges. 15 S.
2023
Abstract
Atemgasanalyse zur Beurteilung und Erfassung von psychischer Beanspruchung bei Stressreaktionen im Arbeitsumfeld
Fachet, Melanie; Haase, Tina; Steigemann, Lea-Marie; Wagner, Leonie Marlene; Cholewinski, D.; Darius, Sabine; Böckelmann, Irina; Arlinghaus, Julia C.; Hoeschen, Christoph
In: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 350-351, Artikel AS16.04 [Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023]
Nachweis psychischer Beanspruchung bei Stressreaktionen im Arbeitsumfeld durch objektive und subjektive Messverfahren
Steigemann, Lea Marie; Wagner, L. M.; Cholewinski, D.; Haase, Tina; Fachet, Melanie; Böckelmann, Irina; Darius, Sabine; Arlinghaus, Julia C.; Hoeschen, Christoph
In: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 166-167, Artikel PS03.09 [Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023]
New insight into peripheral molecular change in major depressive disorder by breathomics analysis
Gbaoui, Laila; Hoeschen, Christoph; Fachet, Melanie; Lüno, Marian; Meyer-Lotz, Gabriela; Frodl, Thomas
In: Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023, 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 348-349, Artikel AS16.03
Buchbeitrag
Multi-class Tissue Segmentation of CT images using an Ensemble Deep Learning method
Mahmoodian, Naghmeh; Chakrabarty, Sumit; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Piscataway, NJ : IEEE . - 2023, insges. 4 S.
Begutachteter Zeitschriftenartikel
U-Net-based SUV calculation in FDG-PET imaging of mice brain for enhanced analysis
Pashazadeh, Ali Mahmout; Jafarian Dehkordi, Forough; Tanha, Kaveh; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 291-294
Calculation of standardized uptake values (SUVs) and time activity curves (TACs) of mice in FDG-PET
Jafarian Dehkordi, Forough; Tanha, Kaveh; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 118-121
Modelling DTPA therapy following Am contamination in rats
Kastl, Manuel; Grémy, Olivier; Lamart, Stephanie; Giussani, Augusto; Li, Wei Bo; Hoeschen, Christoph
In: Radiation and environmental biophysics - Berlin : Springer, Bd. 62 (2023), Heft 4, S. 483-495
Education and training in radiation protection in Europe - results from the EURAMED Rocc-n-Roll project survey
Santos, Joana; Foley, Shane; Andersson, Jonas; Figueiredo, João Paulo; Hoeschen, Christoph; Damilakis, John; Frija, Guy; Alves, Francisco; Riklund, Katrine; Rainford, Louise; Nestle, Ursula; McNulty, Jonathan; Bacher, Klaus; Hierath, Monika; Paulo, Graciano
In: Insights into imaging - Berlin : Springer, Bd. 14 (2023), Artikel 55, insges. 10 S.
Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma
Fachet, Melanie; Mushunuri, Raghava Vinaykanth; Bergmann, Christian B.; Marzi, Ingo; Hoeschen, Christoph; Relja, Borna
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 14 (2023), insges. 15 S.
Estimation of central blood pressure waveform from femoral blood pressure waveform by blind sources separation
Gbaoui, Laila; Hoeschen, Christoph; Kaniusas, Eugenijus; Khatib, Saher; Gretschel, Stephan; Wellnhofer, Ernst
In: Frontiers in Cardiovascular Medicine - Lausanne : Frontiers Media, Bd. 10 (2023), insges. 14 S.
Möglichkeiten der künstlichen Intelligenz im Strahlenschutz
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Die Radiologie - [Berlin] : Springer Medizin Verlag GmbH, Bd. 63 (2023), Heft 7, S. 530-538
The potential role of 3D-printed phantoms in quality control of artificial intelligence-based algorithms in medical imaging
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 295-298
Characterization of a polychromatic microfocus X-ray fluorescence imaging setup with metallic contrast agents in a microphysiological tumor model
Kumar, Kunal; Fachet, Melanie; Al-Maatoq, Marwah; Chakraborty, Amit; Khismatrao, Rahul S.; Oka, Shreyas V.; Staufer, Theresa; Grüner, Florian; Michel, Thilo; Walles, Heike; Hoeschen, Christoph
In: Frontiers in physics - Lausanne : Frontiers Media, Bd. 11 (2023), Artikel 1125143, insges. 19 S.
Artifacts’ detection for MRI non-metallic needles - comparative analysis for artifact evaluation using K-means and manual quantification
AL-Maatoq, Marwah; Fachet, Melanie; Rao, Rajatha Nagaraja; Hoeschen, Christoph
In: Magnetochemistry - Basel : MDPI, Bd. 9 (2023), Heft 3, Artikel 79, insges. 13 S.
Simulation study of the effect of the geometrical parameters on the performance of a beta probe
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 299-302
Optimization techniques for semi-automated 3D rigid registration in multimodal image-guided deep brain stimulation
Al-Jaberi, Fadil; Fachet, Melanie; Moeskes, Matthias; Skalej, Martin; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 355-358
Dynamic stability of volatile organic compounds in respiratory air in schizophrenic patients and its potential predicting efficacy of TAAR agonists
Held, Anna; Henning, Dariush; Jiang, Carina; Hoeschen, Christoph; Frodl, Thomas
In: Molecules - Basel : MDPI, Bd. 28 (2023), Heft 11, Artikel 4385, insges. 15 S.
Gut-brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder
Henning, Dariush; Lüno, Marian; Jiang, Carina; Meyer-Lotz, Gabriela; Hoeschen, Christoph; Frodl, Thomas
In: Journal of psychiatry & neuroscience - Ottawa : CMA, Bd. 48 (2023), Heft 2, S. E117-E125
2022
Abstract
Atemgasanalytik mittels Proton Transfer Reaction-Massenspektrometrie (PTR-MS) - Einfluss von Alltagsfaktoren auf die Messergebnisse
Reckzeh, Marie-Louise; Lowitzki, Simon; Walles, Thorsten; Hoeschen, Christoph; Fachet, Melanie
In: Zentralblatt für Chirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 147 (2022), S 01, S. S84
Buchbeitrag
Liver texture classification on CT images of microwave ablation therapy
Mahmoodian, Naghmeh; Thadesar, Harshita; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: Konferenz: 7th International Conference on Data Science and Machine Learning Applications, CDMA, Riyadh, Saudi Arabia, 01-03 March 2022, 2022 7th International Conference on Data Science and Machine Learning Applications (CDMA) - Piscataway, NJ: IEEE . - 2022, S. 139-144
Detruncation of clinical CT scans using a discrete algebraic reconstruction technique prior
Byl, Achim; Knaup, Michael; Rafecas, Magdalena; Hoeschen, Christoph; Kachelrieß, Marc
In: 7th International Conference on Image Formation in X-Ray Computed Tomography / ICIFXCT , 2022 - Bellingham, Washington, USA : SPIE, S. 1-7, Artikel 123041M, insges. 7 S. [Konferenz: Seventh International Conference on Image Formation in X-Ray Computed Tomography, ICIFXCT 2022, Baltimore, United States, 2022]
Begutachteter Zeitschriftenartikel
Susceptibility artifacts evaluation for non-metallic biopsy needles in a biological-engineered 3D tumor model
Al-Maatoq, Marwah; Fachet, Melanie; Walles, Heike; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 8 (2022), 2, S. 289-292
A concept to combine a gamma probe with ultrasound imaging for improved localization of sentinel lymph nodes - a feasibility study of the concept
Pashazadeh, Ali; Hoeschen, Christoph; Großer, Oliver Stephan; Kreißl, Michael; Kupitz, Dennis; Boese, Axel; Illanes, Alfredo; Friebe, Michael
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 8 (2022), 2, S. 380-383
Carbon nanotube-based reinforced polymers for medical applications - improving impact strength of polymer-polymer composites
AL-Maatoq, Marwah; Fuentealba, Patricio; Fachet, Melanie; Glüge, Rainer; Ali, Salah H. R.; Hoeschen, Christoph
In: Journal of nanomaterials - New York, NY : Hindawi Publ., Bd. 2022 (2022), Artikel 1760198, insges. 15 S.
Volatile organic compounds from breath differ between patients with major depression and healthy controls
Lueno, Marian; Dobrowolny, Henrik; Gescher, Dorothee Maria; Gbaoui, Laila; Meyer-Lotz, Gabriele; Hoeschen, Christoph; Frodl, Thomas
In: Frontiers in psychiatry - Lausanne: Frontiers Research Foundation, 2007, Bd. 13 (2022), insges. 8 S.
Investigation of everyday influencing factors on the variability of exhaled breath profiles in healthy subjects
Fachet, Melanie; Lowitzki, Simon; Reckzeh, Marie-Louise; Walles, Thorsten; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 8 (2022), 2, S. 261-264
Volatile organic compounds from exhaled breath in schizophrenia
Jiang, Carina; Dobrowolny, Henrik; Gescher, Dorothee Maria; Meyer-Lotz, Gabriela; Steiner, Johann; Hoeschen, Christoph; Frodl, Thomas
In: The world journal of biological psychiatry - Abingdon: Taylor & Francis Group, 2000, Bd. 23 (2022), 10, S. 773-784
Comparison of the Y-90 brachytherapy and Ir-192 brachytherapy of skin tumors - a simulation study
Pashazadeh, Ali; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin: De Gruyter, Bd. 8 (2022), 2, S. 388-391
Science and practice of imaging physics through 50 years of SPIE Medical Imaging conferences
Wang, Adam S.; Cunningham, Ian A.; Danielsson, Mats; Fahrig, Rebecca; Flohr, Thomas; Hoeschen, Christoph; Noo, Frederic; Sabol, John M.; Siewerdsen, Jeffrey H.; Tingberg, Anders; Yorkston, John I.; Zhao, Wei; Samei, Ehsan
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, Bd. 9 (2022), S1
Fifty years of SPIE Medical Imaging proceedings papers
Nishikawa, Robert M.; Deserno, Thomas Martin; Madabhushi, Anant; Krupinski, Elizabeth A.; Summers, Ronald M.; Hoeschen, Christoph; Mello-Thoms, Claudia R.; Myers, Kyle J.; Kupinski, Matthew A.; Siewerdsen, Jeffrey H.
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, Bd. 9 (2022), S1
Education and training in radiation protection in Europe - an analysis from the EURAMED rocc-n-roll project
Rainford, Louise; Santos, Joana; Alves, Francisco; Figueiredo, João Paulo; Hoeschen, Christoph; Damilakis, John; Frija, Guy; Andersson, Jonas; McNulty, Jonathan; Foley, Shane; Bacher, Klaus; Nestle, Ursula; Hierath, Monika; Paulo, Graciano
In: Insights into imaging - Berlin: Springer, Bd. 13 (2022), insges. 10 S.
Exploring the translational challenge for medical applications of ionising radiation and corresponding radiation protection research
Bockhold, Sophie; Foley, Shane J.; Rainford, Louise A.; Corridori, Riccardo; Eberstein, Annika; Hoeschen, Christoph; Konijnenberg, Mark W.; Molyneux-Hodgson, Susan; Paulo, Graciano; Santos, Joana; McNulty, Jonathan P.
In: Journal of translational medicine - London: BioMed Central, Bd. 20 (2022), 1, insges. 10 S.
Segmentation of living and ablated tumor parts in CT images using ResLU-Net
Mahmoodian, Naghmeh; Thadesar, Harshita; Sadeghi, Maryam; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 8 (2022), 2, S. 49-52
Notifications and alerts in patient dose values for computed tomography and fluoroscopy-guided interventional procedures
Vano, Eliseo; Loose, Reinhard; Frija, Guy; Paulo, Graciano; Efstathopoulos, Efstathios; Granata, Claudio; Corridori, Riccardo; Torresin, Alberto; Andersson, Jonas S.; Tsapaki, Virginia; Ammon, Josefin; Hoeschen, Christoph
In: European radiology - Berlin: Springer, Bd. 32 (2022), 8, S. 5525-5531
Breathomics profiling of metabolic pathways affected by major depression - possibilities and limitations
Gbaoui, Laila; Fachet, Melanie; Lüno, Marian; Meyer-Lotz, Gabriele; Frodl, Thomas; Hoeschen, Christoph
In: Frontiers in psychiatry - Lausanne: Frontiers Research Foundation, Bd. 13 (2022), insges. 17 S.
Medical applications of ionizing radiation and radiation protection for European patients, population and environment
Thierry-Chef, Isabelle; Cardis, Elisabeth; Damilakis, John; Frija, Guy; Hierath, Monika; Hoeschen, Christoph
In: EPJ Nuclear Sciences & Technologies - Les Ulis : EDP Sciences, Bd. 8 (2022), Artikel 44, insges. 8 S.
Dissertation
Quality assessment of clinical thorax CT images
Passand, Zahra; Hoeschen, Christoph
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektrotechnik und Informationstechnik 2022, 1 Online-Ressource (II, 101 Seiten, 7,43 MB) [Literaturverzeichnis: Seite 87-99]
2021
Abstract
Liver ablation segmentation of CT images in microwave ablation therapy
Mahmoodian, Naghmeh; Georgiades, Marilena; Hoeschen, Christoph
In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 13
Multimodal image fusion for determination of electrode location in deep brain stimulation
Al-Jaberi, Fadil; Fachet, Melanie; Moeskes, Matthias; Skalej, Martin; Hoeschen, Christoph
In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 49
Begutachteter Zeitschriftenartikel
ESR EuroSafe Imaging and its role in promoting radiation protection - 6 years of success
Frija, Guy; Hoeschen, Christoph; Granata, Claudio; Vano, Eliseo; Paulo, Graciano; Damilakis, John; Donoso, Lluis; Bonomo, Lorenzo; Loose, Reinhard; Ebdon-Jackson, Steve
In: Insights into imaging - Berlin: Springer, Bd. 12 (2021), 1, insges. 12 S.
Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System) - effect of metal artifacts on a SPECT-CT-based quantification
Großer, Oliver Stephan; Klutzny, Marcus; Wissel, Heiko; Kupitz, Dennis; Finger, Michael; Schenke, Simone; Wüstemann, Jan; Lohmann, Christoph H.; Hoeschen, Christoph; Pech, Maciej; Stärke, Christian; Kreißl, Michael
In: EJNMMI Physics - Berlin: SpringerOpen, Bd. 8 (2021), Artikel 15, insges. 15 S.
Dissertation
X-ray fluorescence imaging - experimental and numerical analysis of a crystal based concept
Rosentreter, Tanja; Hoeschen, Christoph
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2021, x, 147 Seiten [Literaturverzeichnis: Seite 137-144][Literaturverzeichnis: Seite 137-144]
2020
Abstract
Breathomics for depressive disorders
Lüno, Marian; Meyer-Lotz, Gabriela; Metzger, Coraline Danielle; Gescher, Dorothee Maria; Hoeschen, Christoph; Gbauoui, Laila; Frodl, Thomas
In: Pharmacopsychiatry - Stuttgart [u.a.] : Thieme - Bd. 53.2020, 2, P.2.7, S. 83
Buchbeitrag
Image quality assessment of real patient thorax CT images using modulation transfer function and noise power spectrum
Passand, Zahra; Hoeschen, Christoph
In: Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, 1963, Bd. 11312.2020[Konferenz: Medical Imaging 2020, 15-20 February 2020]
Begutachteter Zeitschriftenartikel
Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state
Gomolka, Maria; Blyth, Benjamin; Bourguignon, Michel; Badie, Christophe; Schmitz, Annette; Talbot, Christopher; Hoeschen, Christoph; Salomaa, Sisko
In: International journal of radiation biology - London: Taylor & Francis, Bd. 96.2020, 3, S. 280-296
Einsatz künstlicher Intelligenz für die Bildrekonstruktion
Hoeschen, Christoph
In: Der Radiologe - Berlin: Springer, Bd. 60 (2020), 1, S. 15-23
Current status of radioactive waste management in Afghanistan
Tanha, Mohammad R.; Hanafiah, Marlia M.; Khalid, Fazal R.; Storai, Mohammad A.; Hoeschen, Christoph
In: Journal of radioanalytical and nuclear chemistry: an international journal dealing with all aspects and applications of nuclear chemistry - Dordrecht [u.a.]: Springer Science + Business Media B.V., Bd. 323.2020, 2, S. 715-720
Clinical and epidemiological observations on individual radiation sensitivity and susceptibility
Seibold, Petra; Auvinen, Anssi; Averbeck, Dietrich; Bourguignon, Michel; Hartikainen, Jaana M.; Hoeschen, Christoph; Laurent, Olivier; Noel, Georges; Sabatier, Laure; Salomaa, Sisko; Blettner, Maria
In: International journal of radiation biology - London: Taylor & Francis, Bd. 96.2020, 3, S. 324-339
2019
Buchbeitrag
Activity concentration and annual effective dose estimation of 210Pb, 40K and 137Cs in soils of southern Algeria
Nadri, M.; Tanha, Mohammad R.; Hoeschen, Christoph; Khiari, C.; Ioannidou, A.
In: International journal of environmental science and technology: IJEST - Tehran: Islamic Azad University, 2019[Online first]
Begutachteter Zeitschriftenartikel
Strategic research agenda for biomedical imaging
Aime, S.; Alberich, A.; Almen, A.; Arthurs, O. J.; Barthel, H.; Clément, O.; Crean, M.; Souza, N.; Demuth, F.; Dewey, V.; Dousset, V.; Frangi, A.; Garos, C.; Golay, X.; Gordebeke, P.; Günther, M.; Hahn, H.; Hierath, M.; Hoeschen, Christoph; Hunink, M.; Kauczor, H. U.; Krestin, G.; Krischak, K.; Langs, G.; Liu, Y.; Marti-Bonmati, L.; Matos, C.; Mayerhofer-Sebera, U.; McNulty, J.; Muylle, K.; Neeman, M.; Niessen, W.; Nikolaou, K.; Pereira, P.; Persson, A.; Pifferi, A.; Riklund, K.; Rockall, A.; Rosendahl, K.; Sardanelli, F.; Sourbron, S.; Speck, Oliver; Valentini, V.; Zolda, P.
In: Insights into imaging - Berlin: Springer, Volume 10 (2019), article number 7,insgesamt 14 Seiten
Assessment of radiation protection and awareness level among radiation workers and members of the public in Afghanistan - a pilot study
Tanha, Mohammad R.; Khalid, Fazal Rahman; Hoeschen, Christoph
In: Journal of radiological protection - Bristol: IOP Publ. . - 2019
A method of determining geometry of cone beam CT scanner
Tischenko, Oleg; Saeidnezhad, Nazila; Hoeschen, Christoph
In: Biomedical physics & engineering express - Bristol: IOP Publ., Bd. 5 (2019), 5, insges. 14 S.
2018
Buchbeitrag
Assessment of image quality parameters of a novel micro-CT system compared to a conventional CT geometry
Kumar, Kunal; Saeidnezhad, Nazila; Müller, Bernhard H.; Tischenko, Oleg; Hoeschen, Christoph
In: Konferenz: SPIE Medical Imaging, 2018, Houston, Texas, United States, Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, Bd. 10573 (2018)
Begutachteter Zeitschriftenartikel
Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects
Grüner, F.; Blumendorf, F.; Schmutzler, O.; Staufer, T.; Bradbury, M.; Wiesner, U.; Rosentreter, T.; Loers, G.; Lutz, D.; Richter, B.; Fischer, M.; Schulz, F.; Steiner, S.; Warmer, M.; Burkhardt, A.; Meents, A.; Kupinski, M.; Hoeschen, Christoph
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Vol. 8.2018,1, Artikelnummer 16561
EURAMEDs vision on medical radiation protection (research)
Hoeschen, Christoph
In: Annals of the ICRP/ International Commission on Radiological Protection - London [u.a.]: Sage, Bd. 47 (2018), 3-4, S. 152-158
A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice
Kistler, Martin; Muntean, Andreea; Höllriegl, Vera; Matuschek, Georg; Zimmermann, Ralf; Hoeschen, Christoph; Hrabě de Angelis, Martin; Rozman, Jan
In: Journal of breath research: volatiles for medical diagnosis : official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR) - Bristol: IOP, Bd. 12.2018, 1, insges. 9 S.
Determination and verification of the x-ray spectrum of a CT scanner
Hassan, Ahmad Ibrahim; Skalej, Martin; Schlattl, Helmut; Hoeschen, Christoph
In: Journal of medical imaging - [Bellingham, Wash.] : SPIE - Bd. 5.2018, 1, Art.-Nr. 013506, insges. 15 S.
Lifetime study in mice after acute low-dose ionizing radiation - a multifactorial study with special focus on cataract risk
Dalke, Claudia; Neff, Frauke; Kaur Bains, Savneet; Bright, Scott; Lord, Deborah; Reitmeir, Peter; Rößler, Ute; Samaga, Daniel; Unger, Kristian; Braselmann, Herbert; Wagner, Florian; Greiter, Matthias; Gomolka, Maria; Hornhardt, Sabine; Kunze, Sarah; Kempf, Stefan J.; Garrett, Lillian; Hölter-Koch, Sabine; Wurst, Wolfgang; Rosemann, Michael; Azimzadeh, Omid; Tapio, Soile; Aubele, Michaela; Theis, Fabian; Hoeschen, Christoph; Slijepcevic, Predrag; Kadhim, Munira; Atkinson, Michael; Zitzelsberger, Horst; Kulka, Ulrike; Graw, Jochen
In: Radiation and environmental biophysics - Berlin : Springer . - 2018, insges. 15 S.
2017
Buchbeitrag
Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging
Rosentreter, Tanja; Müller, Bernhard; Schlattl, Helmut; Hoeschen, Christoph
In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 10132 (2017), Artikel 101325P
Novel method to calibrate CT scanners with a conic probe body
Tischenko, O.; Saeednejad, N.; Hoeschen, Christoph
In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 10132 (2017), Artikel 101322Q
Begutachteter Zeitschriftenartikel
Feasibility of reducing differences in estimated doses in nuclear medicine between a patient-specific and a reference phantom
Zvereva, Alexandra; Schlattl, Helmut; Zankl, Maria; Becker, Janine; Petoussi-Henss, Nina; Yeom, Soo Yeon; Kim, Chan Hyeong; Hoeschen, Christoph; Parodi, Katia
In: Physica medica: European journal of medical physics : an international journal devoted to the applications of physics to medicine and biology - Amsterdam: Elsevier, Bd. 39.2017, S. 100-112
Anthropomorphic dual-lattice voxel models for optimizing image quality and dose
Petoussi-Henss, Nina; Schlattl, Helmut; Becker, Janine; Greiter, Matthias; Zankl, Maria; Hoeschen, Christoph
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, 2014, Bd. 4.2017, 1, Art.-Nr. 013509, insges. 10 S.
Herausgeberschaft
Special section guest editorial - visions of safety : perspectives on radiation exposure and risk in medical imaging
Samei, Ehsan; Hoeschen, Christoph
In: [Bellingham, Wash.]: SPIE, 2017 - (Journal of medical imaging; Vol. 4.2017,3)
2016
Buchbeitrag
Conceptual detector development and Monte Carlo simulation of a novel 3D breast computed tomography system
Ziegle, Jens; Müller, Bernhard H.; Neumann, Bernd; Hoeschen, Christoph
In: Konferenz: SPIE Medical Imaging, 2016, San Diego, California, United States, Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, Bd. 9783 (2016)
Begutachteter Zeitschriftenartikel
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice
Kistler, Martin; Muntean, Andreea; Szymczak, Wilfried; Rink, Nadine; Fuchs, Helmut; Gailus-Durner, Valerie; Wurst, Wolfgang; Hoeschen, Christoph; Klingenspor, Martin; Hrabě de Angelis, Martin; Rozman, Jan
In: Journal of breath research: volatiles for medical diagnosis : official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR) - Bristol: IOP, Vol. 10.2016, 1, Art. 016009, insgesamt 16 S.
Optimisation in x-ray and molecular imaging 2015
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Radiation protection dosimetry - Ashford: Oxford Univ. Press, 1981, Bd. 169.2016, 1/4, S. 1-439[Konferenz: "This issue is based on contributions to Optimisation in X-ray and Molecular Imaging 2015the 4th Malmö Conference on Medical Imaging (OXMI 2015), which was held from 28 to 30 May 2015 at Sahlgrenska University Hospital/University of Gothenburg in Gothenburg, Sweden.]
Uncertainty quantification in internal dose calculations for seven selected radiopharmaceuticals
Spielmann, Vladimir; Li, Wei Bo; Zankl, Maria; Oeh, Uwe; Hoeschen, Christoph
In: Journal of nuclear medicine: JNM - New York, NY: Soc, Bd. 57.2016, 1, S. 122-128
Effect of blood activity on dosimetric calculations for radiopharmaceuticals
Zvereva, Alexandra; Petoussi-Henss, Nina; Li, Wei Bo; Schlattl, Helmut; Oeh, Uwe; Zankl, Maria; Graner, Frank Philipp; Hoeschen, Christoph; Nekolla, Stephan G.; Parodi, Katia; Schwaiger, Markus
In: Physics in medicine and biology: an official journal of the Institute of Physics and Engineering in Medicine - Bristol: IOP Publ, Bd. 61.2016, 21, S. 7688-7703
Optimisation in X-ray and molecular imaging 2015[Editorial]
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Radiation protection dosimetry - Ashford: Oxford Univ. Press, Bd. 169.2016, 1/4, S. 1
Herausgeberschaft
OXMI 2015$proceedings of Optimisation in X-ray and Molecular Imaging 2015 - the 4th Malmö Confeerence on Medical Imaging
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Oxford Press, 2016, 1 Online-Ressource - (Radiation protection dosimetry; 169,1/4)
2015
Begutachteter Zeitschriftenartikel
Simulation on the molecular radiosensitization effect of gold nanoparticles in cells irradiated by x-rays
Xie, W. Z.; Friedland, W.; Li, W. B.; Li, C. Y.; Oeh, U.; Qiu, R.; Li, J. L.; Hoeschen, Christoph
In: Physics in medicine and biology: an official journal of the Institute of Physics and Engineering in Medicine - Bristol: IOP Publ., Vol.60.2016, 16, Art. 6195, insgesamt 19 S., 2015
Feasibility of spectral CT imaging for the detection of liver lesions with gold-based contrast agents - a simulation study
Müllner, Marie; Schlattl, Helmut; Hoeschen, Christoph; Dietrich, Olaf
In: Physica medica - Amsterdam: Elsevier, Bd. 31 (2015), 8, S. 875-881
Task-based measures of image quality and their relation to radiation dose and patient risk
Barrett, Harrison H.; Myers, Kyle J.; Hoeschen, Christoph; Kupinski, Matthew A.; Little, Mark P.
In: Physics in medicine and biology - Bristol : IOP Publ., Bd. 60 (2015), Heft 2, insges. 76 S.
2014
Begutachteter Zeitschriftenartikel
Age-dependent inhalation doses to members of the public from indoor short-lived radon progeny
Brudecki, Kamil; Li, Wei Bo; Meisenberg, Oliver; Tschiersch, Jochen; Hoeschen, Christoph; Oeh, Uwe
In: Radiation and environmental biophysics - Berlin: Springer, Bd. 53.2014, 3, S. 535-549
Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA
Kastl, Manuel; Giussani, Augusto; Blanchardon, Eric; Breustedt, Bastian; Fritsch, Paul; Hoeschen, Christoph; Lopez, Maria Antonia
In: International journal of radiation biology - London: Taylor & Francis, Bd. 90.2014, 11, S. 1062-1067
2009
Zeitschrift/Serie
Only therapeutic ICOS:ICOSL blockade alleviates acute graft versus host disease.
Mollweide, A; Staege, M S; Hoeschen, C; Hideo, Y; Burdach, S; Richter, G H S
In: Klinische Pädiatrie, Vol. 221, 2009, S. 344-50, ISSN 1439-3824, 10.1055/s-0029-1239532
2002
Originalartikel in begutachteter nationaler Zeitschrift
Optimierte Bildverarbeitung durch ein modifiziertes Pre-Processing von Bilddatensätzen eines transparenten Speicherfoliensystems am Beispiel der seitlichen HWS-Aufnahme.
Reissberg, Steffen; Hoeschen, Christoph; Redlich, Ulf; Scherlach, Cordula; Preuss, Heide; Kaestner, Andrea; Woischneck, Dieter; Schuetze, Michael; Reichardt, Kerstin; Firsching, Raimund; Doehring, Wilfried
In: RöFo Fortschr. Geb. Röntgenstr. 174(2002), S. 1296 - 1300
- Kirchoff Institut für Physik, Heidelberg
- Forschungszentrum Jülich
- Nuevo Hospital La Fe, Valencia
- Universitätsklinikum Magdeburg
- Städtisches Klinikum Magdeburg
- Helmholtz Zentrum München
- Bayer AG Radiology
- AGFA Healthcare
- CERN
- Coimbra Health school, Portugal
- CREAL, Barcelona
- EIBIR, Wien
- ETH Zürich
- Eckert & Ziegler Strahlen- und Medizintechnik AG, Berlin - Seed Imaging
- LMU München
- MedAustron
- Uni Erlangen
- Uni Hamburg
- University of Rome "Tor Vergata", Italy, Prof. L. Santo
- HNO Klinik, OvGU, Prof. Christoph Arens
- MHH, Prof. Dr. med. Frank Wacker
- MOXTEK Inc., Salt Lake City, USA
- National Institute of Standards and Technology (NIST)
- Orthopädische Universitätsklinik, Magdeburg
- OVGU Magdeburg, Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie (KHNO)
- OVGU Magdeburg, Universitätsklinik für Herz- und Thoraxchirurgie (KCHH)
- OVGU Magdeburg, Universitätsklinik für Strahlentherapie
- OVGU Radiologie, Prof. Fischbach, Prof. Pech
- Siemens Healthcare GmbH
- Universitätsklinikum Magdeburg, Institut für Pathologie
- Bundesamt für Stahlenschutz
- CEA - French Alternative Energies and Atomic Energy Commission
- CESCA-FUNDACION PUBLICA GALLEGA CENTRO TECNOLOGICO DE SUPERCOMPUTACION DE GALICIA
- COCIR - European Coordination Committee of the Radiological, Electromedical and healthcare IT Industry
- DESY, Hamburg
- DKFZ - Deutsches Krebsforschungszentrum
- ECCO - European CanCer Organisation
- Erasmus universitair medisch centrum Rotterdam
- EURAMED - European Alliance for Medical Radiation Protection Research
- European University of Cyprus
- Fondazione Toscana Gabriele Monasterio
- IRSN - Institut de Radioprotection et de Sûreté Nucléaire
- Istituto Giannina Gaslini
- JAN KOCHANOWSKI UNIVERSITY
- Katholische Universität Leuven
- NARODOWE CENTRUM BADAN JADROWYCH
- Nemzeti Népegészségügyi Központ
- NKI - Stichting Het Nederlands Kanker Instituut–Antoni van Leeuwenhoek Ziekenhuis
- QAELUM NV
- Ruder Boškovic Institute
- Sahlgrenska university hospital, Göteborg
- SCK-CEN: Studiecentrum voor Kernenergie
- SERVIZO GALEGO DE SAUDE
- SKANDION - KOMMUNALFORBUNDET AVANCERAD STRALBEHANDLING
- Stockholms Universitet
- STUK - Radiation and Nuclear Safety Authority Finnland
- SWIETOKRZYSKIE CENTRUM ONKOLOGII
- Universitaetsklinikum Freiburg
- Universität Hamburg (Prof. Grüner), Hamburg
- Universität Lübeck
- Universität Mainz, Klinik für Diagnostische und Interventionelle Radioogie
- Universitätsklinik für Psychiatrie und Psychotherapie, OvGU, Prof. Frodl
- Universität Zagreb
- UNIVERSITE DE GENEVE
- UNIVERSITEIT GENT
- Université Paris Descartes
- University Hospital Descartes, Paris
- University Medical Center Ljubljana
- university of crete, Kreta
- University of Dublin
- University of Exeter
- University of Umea
- University Tartu
- VHIO - Fundacio Privada Institut D’Investigacio Oncologica de Vall-Hebron
- Vrije Universiteit Brussels
- Dosimetrie
- medizinischer Strahlenschutz
- Bildgebung mit speziellen Röntgenquellen
- nuklearmedizinische Bildgebung
- biokinetische Modellierung
- Atemluftanalytik
- Medizinphysik
- Medizinphysikberatungen
- Strahlenschutzkommission verschiedenen Funktionen in Ausschuss "Strahlenschutztechnik" und Arbeitsgruppen
- EURAMED (europäische Platform für medizinischen Strahlenschutz) chair
1996-1999 wissenschaftlicher MA, PTB Braunschweig, EU Projekt
1999-2004 wissenschaftlicher MA, Uniklinikum Magdeburg, Radiologie
2002 Promotion Dr. rer. nat. Otto-von-Guericke-Universität Magdeburg
2004-2010 Gruppenleiter "Medizinphysik" Helmholtz Zentrum München (früher GSF)
2007 Behnken-Berger- Preis, 1. Platz
2010-2016 Abteilungsleiter "Medizinische Strahlungsphysik und Diagnostik", Helmholtz Zentrum München
2011-2013 zusätzlich Abteilungsleiter "Auswertestelle Personendosimetrie"
seit 2014 W3 Professor "Medizintechnische Systeme" Institut für Medizintechnik, Fakultät für Elektrotechnik und Informationstechnologie, Otto-von-Guericke Universität Magdeburg
seit Oktober 2016 Prodekan ebenda